PI3Kδ is indispensable for CTL-mediated cytotoxicity
نویسندگان
چکیده
Background The expression of catalytic phosphoinositol-3-kinase isoform δ (PI3Kδ) is restricted to the haematopoetic compartment. Accordingly, PI3Kδ serves as a drug target to eliminate leukaemic cells. However, we previously showed that PI3Kδ is indispensable for the function of natural killer (NK)-cells [1]. Thus, the therapeutic success of PI3Kδ inhibitors is likely to be compromised by unintended side effects on the immune system. Besides NK-cells, CD8 cytotoxic T-cells (CTLs) are well-known key players in natural host response against developing tumours and viral infections. In this study, we examine the role of PI3Kδ for CTL function and CTL-mediated tumour surveillance.
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011